I know most fans have read the issue by now, and while I'd love very much to talk plainly about the plot of this issue, I don't plan on spoiling anything until at least next Wednesday. So, with that in mind, I'll launch into what I hope is a mostly spoiler-free review.
It is the writing of this issue that will take center stage, as things are laid out in the form of a typical slice-of-life vignette from Spidey's point of view. He starts off web-slinging through the city in a carefree manner, moves to intercept a small-time crook robbing a business, and then glides into the non-superhero aspects of Peter Parker's life. We see that Aunt May, Mary Jane, and Horizon Labs occupy the lion's share of Peter's time, and he moves smoothly through each of them with newfound boldness and confidence until he receives a distress call from his teammates on the Avengers.
He meets them at the Raft, a prison for super-powered inmates administered by S.H.I.E.L.D. When he's told that Doctor Octopus is moments away from finally dying, Spider-Man asks for a private moment with him. In the final pages and panels of the issue, they have a brief exchange that changes the entire dynamic of the story and suddenly makes for a harrowing, if not outright horrifying realization.
If you've kept abreast of what's going on and what will be happening in Spidey's universe, you knew this issue would be the start of a harrowing ride. For me personally, that still did nothing to help me prepare emotionally for the revelation that pops up here. With the #700 finale just around the corner and the new Superior Spider-Man title coming out soon, this final arc has my full attention. I'm sure the rest of Spidey's readers will agree. Highly recommended.
I'll have a more spoiler-y video review/reaction next week.